Mekdela Amba University has identified five research thematic areas with total number of 67 sub-themes under mentioned thematic areas. These themes are prioritized largely based on the recent differentiation made by the university.

Theme 1: Agricultural Productivity and Natural Resource Management
Sub-Theme 1: Livestock Husbandry and marketing system
Sub-Theme 2: Animal Health and welfare management
Sub-Theme 3: Field and Horticultural Crop Husbandry
Sub-Theme 4: Factors of productivity and efficiency
Sub-Theme 5: Livelihood strategies and Disaster Risk Management

Sub-Theme 6: Value Addition Process and Chain Management
Sub-Theme 7: Sustainable Agriculture, Food Security, and Rural Development
Sub-Them 8. Ecosystem Sustainability, Resource Management, and Climate Resilience
Sub-Theme 9: Biodiversity, Energy, and Environmental Sustainability
Sub-Theme 10: Sustainable Forestry, Agroforestry, and Biodiversity Conservation
Sub-theme 11: Climate Change, Natural Resources, and Socioeconomic Impacts
Sub theme 12: Agricultural policies and rural livelihoods
Subtheme 13: Poverty alleviation strategies in rural communities

Theme 2: Mining and Application of Basic Sciences
Sub Theme 1: Earth resources Exploration, extraction and processing
Sub Theme 2: Geological Hazards and Natural Disasters
Sub Theme 3: Modeling and Software Simulation
Sub Theme 4: Health and well being

Theme 3: Culture and Tourism
Sub Theme 1: Culture and Social Development
Sub Theme 2: Identity and Heritage
Sub Theme 3: Arts and Creative Practices
Sub Theme 4: Indigenous knowledge system
Sub theme 5: Traditional festivals and cultural events
Sub theme 6: Heritage sites, historical landmarks and traditional crafts
Sub theme 7: Cultural tourism marketing and promotion strategies
Sub theme 8: Cultural heritage and tourism development practices
Sub theme 9: Leadership and organizational behavior
Sub theme 10: Marketing ethics

Theme 4: Technology and Innovation
Sub Theme 1: Innovation and Technology for Development
Sub Theme 2: Artificial Intelligence and Robotics
Sub Theme 3: Telecommunications
Sub Theme 4: IT infrastructure
Sub Theme 5: Digital economy
Sub Theme 6: Digital inclusion
Sub Theme 7: Cybersecurity
Sub Theme 8: Emerging technologies
Sub Theme 9: Cross-cutting digital technologies
Sub theme 10: Digital Marketing and social media
Sub theme 11: Product development and innovation
Sub theme 12: Marketing communication and advertising effectiveness
Sub theme 13: Operations management

Theme 5: Business and Humanities
Sub Theme 1: Language and Social Development
Sub Theme 2: Media and Communication
Sub Theme 3: History and Historical Consciousness
Sub Theme 4: Philosophy, Ethics, and Human Values
Sub Theme 5: Literature, Language, and Communication
Sub Theme 6: Gender and youth

Sub Theme 7: Urbanization, Space, and Society
Sub Theme 8: Religion, Belief Systems, and Spirituality
Sub Theme 9: Law and Governance
Sub Theme 10: Social and Cultural Dynamics
Sub Theme 11: Social and Behavioral sciences
Sub theme 12: Consumer behavior and decision making
Sub theme 13: Brand management and branding strategies
Sub theme 14: Market segmentation and targeting
Sub theme 15: Pricing strategies
Sub theme 16: Marketing analytics and international marketing
Sub theme 17: Gender disparities, microfinance and economic development
Sub theme 18: Informal economy
Sub theme 19: Trade policies and local businesses
Sub theme 20: Urbanization trends and economic implications
Sub theme 21: Labor market dynamics, investment opportunities and income inequality
Sub theme 22: Financial reporting and disclosure practices
Sub theme 23: Taxation and auditing practices
Sub theme 24: Financial derivatives, IFRS and capital markets
Sub theme 25: Evaluation of local government budget allocations
Sub theme 26: Entrepreneurship and small business development
Sub theme 27: Human resource management (HRM)